ENZYMIC CATALYSIS OF THE KETO-ENOL TAUTOMERIZATION OF PHENYLPYRUVIC ACIDS
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چکیده
منابع مشابه
Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids.
The present paper describes a new enzyme from animal tissues which catalyzes the keto-enol tautomeriaation of the phenylpyruvic acids. Preliminary accounts of this tautomerase have been published (1, 2). The enzyme has not yet proved to be essential in any biological reaction, but a physiological role may be expected since specific tautomers of a-keto acids are substrates or products in some re...
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The enol of a-cyano-a-phenylacetic acid was observed as a short-lived transient species formed upon flash photolytic generation of phenylcyanoketene by a photo-Wolff reaction of a-cyano-a-diazoacetophenone followed by hydration of the ketene. Rates of ketonization of the enol were measured in dilute hydrochloric acid solutions and acetic acid, biphosphate ion, tris(hydroxymethyl)methylamine, an...
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Group transfer reactions catalyzed by enzymes have assumed a position of intense interest in contemporary enzymology (1). Well known examples of radicals capable of being transferred in such reactions are methyl, glycosyl, aeetyl, phosphoryl, pept,idyl, nucleosidyl, and nucleotidyl, in addition to the transport of hydrogen as seen with the familiar nuoleot.ide coenzymes. In this paper we wish t...
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We theoretically investigate the mechanism of tautomerism in the gas-phase acetylacetone molecule. The minimum energy path between the enolone and diketo forms has been computed using the Nudged-Elastic Band (NEB) method within the density-functional theory (DFT) using the projector augmented-wave method and generalized gradient approximation in Perdew-Wang (PW91) parametrization. The lowest tr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64866-5